Open Access
Peer-Reviewed Article
22 pages • 890 KB PDF
Graph Neural Networks and Diffusion Models for De Novo Structural Protein Design and Crop Pathogen Resistance
Structure-Guided Computational Biology for Enhanced Crop Immunity
by Mei-Ling Zhou, Carlos Mendez, Vikram S. Mehta
J. Deep Sci. Tech. Consort. 2026, 1(1), 103 • https://doi.org/10.69001/jdstc.2026.0103 • Published 30 Aug 2026
Abstract: Plant fungal pathogens continually evolve resistance to chemical fungicides. Here, we present AlphaCrop-Diff, an equivariant graph neural network coupled with conditional diffusion models to design de novo antimicrobial peptides that selectively disrupt fungal cell walls without phytotoxic effects on host crops. [...] Read Full Article →